International Journal of Scientific Reports

Permanent URI for this collection

https://imsear.searo.who.int/handle/123456789/162466

Editor: Dr. Bhaven Kataria
ISSN: (Print) 2454-2156 (Online) 2454-2164

Frequency: Quarterly

Language: English

Open Access Peer-reviewed journal

Web site: https://www.sci-rep.com

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Now showing 1 - 20 of 267

Combination therapy for hypertension management: insights from the Indian experts
(Medip Academy, 2024-06) Jain, P; Jha, SC
Cardiovascular diseases (CVDs) pose a significant global health challenge, with India bearing a disproportionate burden of CVD-related morbidity and mortality. Hypertension (HTN) is a major risk factor for CVDs, affecting nearly 30% of the Indian population. Achieving target blood pressure (BP) levels is crucial for reducing cardiovascular risk, necessitating aggressive antihypertensive therapy. Combination therapy has emerged as a cornerstone in HTN management, especially in high-risk patients. This review delves into the literature and perspectives of Indian cardiologists on combination therapy for HTN management. Despite the efficacy of contemporary antihypertensive medications, a substantial proportion of patients fail to reach target BP levels with monotherapy. Combination therapy offers synergistic effects, addressing multiple pathways involved in HTN pathogenesis. Recent guidelines recommend initiating treatment with two-drug combinations, transitioning to three-drug combinations in resistant cases. Combination therapy not only enhances BP control but also reduces the risk of cardiovascular events and mortality compared to monotherapy. Optimal management of HTN requires personalized approaches, considering individual patient profiles and comorbidities such as coronary artery disease (CAD), diabetes mellitus (DM), dyslipidemia, and heart failure (HF). In such cases, combination therapy plays a pivotal role in mitigating cardiovascular risks. ARB/CCB combination therapy, particularly telmisartan/amlodipine, demonstrates significant efficacy and tolerability across various patient populations, including those with metabolic risk factors and renal impairment. Expert recommendations highlight the importance of individualized therapy, patient education, early diagnosis, and initiation with dual therapy in India. Strategies to improve medication adherence and compliance, such as single-pill double or triple combinations, are emphasized. Moreover, awareness of newer treatment options and contactless diagnostic instruments is crucial for optimizing HTN management. In conclusion, combination therapy stands as a cornerstone in HTN management, offering enhanced efficacy, tolerability, and cardiovascular protection. Tailored approaches guided by expert recommendations are essential to address the growing burden of HTN and reduce the socioeconomic impact of CVDs in India.
Antibiotic resistance situation in Pabna, Bangladesh: a review
(Medip Academy, 2024-05) Amran, MS; Ibrahim, MN; Amanna, FT
Antibiotic abuses and overuses are factors in the global issue of antibiotic resistance (ABR) which is becoming more acute in densely populated urban areas. To offer a concise summary of the present status of ABR in Pabna city, identify any deficiencies and generate recommendations based on findings, a comprehensive analysis was performed. We conducted a search for articles related to ABR published between 2003 to 2022 using search engines such as Google Scholar, PubMed, online and offline journals in Bangladesh. In the past, it was possible to determine the median and interquartile ranges of an organism’s ABR. Forty-two research articles were included in this review. For determining antibiotic susceptibility, approximately 95.96% of the investigations used the disk diffusion method, and about 91.98% followed the clinic and laboratory standards institute’s recommendations. However, information about susceptibility testing procedures and the source of infections-whether they were hospital-based or community-based-was conspicuously absent from about 11.19%, 12.62%, and 92.24% of the study studies, respectively. Many of the diseases studied exhibited high levels of resistance, and traditional first-line antibiotics were largely ineffective. Most of the patients displayed only mild resistance to carbapenem. A developing trend in ABR across the majority of antibiotic classes was also revealed by our findings, in addition to severe monitoring and informational gaps.
Explanation based on thermodynamic parameters regarding effect of sensing film thickness and amount of graphene oxide on sensor performance in aniline, N-phenylglycine and graphene oxide based electrochemical heavy metal ion sensor
(Medip Academy, 2024-07) Dutta, K; Panda, S.
Background: To construct a heavy metal ion sensor, selectivity and sensitivity are the key important parameters to be taken care of. In our earlier work, film thickness and amount of graphene oxide (GO) content in a novel composite ANGO, synthesized from aniline, N-phenylglycine and GO was varied and sensing parameters including sensitivity, limit of detection (LOD), thermodynamic parameter which includes -?Gad and charge transport parameter including barrier width (BW), d, of charge transfer based on Simmon’s model were evaluated and compared and an LOD of 800 ppt for Cd2+ was achieved using square wave voltammetry (SWV) withstanding interference from several ions. Methods: In this work, thermodynamic factors such as -?Gad, ?H, reorganization energy, partition coefficient and solvated ionic radius were used to explain the sensor performance with respect to film thickness and amount of GO. All the parameters were analyzed for different film thicknesses and amount of GO and a correlation was achieved. Finally, effect of electrochemical surface area of different polyaniline-based material on thermodynamic properties of detection process of Cd2+ was studied. Results: The variation of the thermodynamic properties for Cd2+ sensing with respect to film thickness and amount of GO were examined. Similarly, variation of thermodynamic properties for polyaniline based different sensing materials were examined. Correlation coefficients were developed from the thermodynamic parameters and the d values to explain the underlying mechanism behind improved sensor performance. Conclusions: This study can provide information on the thermodynamic properties which can be predicted from BW technique. The correlation coefficients would help in designing polyaniline based novel sensing film material with the need of lesser number of experiments.
Vamorolone: revolutionizing Duchenne muscular dystrophy treatment
(Medip Academy, 2024-05) Mukhtar, S; Haris, M.
Duchenne muscular dystrophy (DMD) is a severe inherited neuromuscular disorder characterized by a dystrophin gene mutation, leading to progressive muscle weakness and structural degradation. Current management strategies focus on multidisciplinary approaches to mitigate symptoms and enhance quality of life. Conventional glucocorticoids present challenges due to their complex nature and severe side effects. Vamorolone, a first-in-class dissociative steroidal drug recently Food and Drug Administration (FDA) - approved, distinguishes itself through enduring anti-inflammatory effects with reduced safety concerns. Pharmacologically, Vamorolone's mechanism of action, differentiating it from traditional corticosteroids, involves selective glucocorticoid receptor (GR) modulation and mineralocorticoid receptor (MR) antagonism, offering improved safety and tolerability. Notably, its unique ?9,11 modification prevents adverse receptor interactions, demonstrating superior safety in inhibiting inflammation across various cell types. This article explores Vamorolone's pharmacokinetics, drug interactions, and adverse effects, underscoring its well-tolerated profile with reversible hypothalamic-pituitary-adrenal axis suppression as a notable concern. Comparative studies against prednisone reveal Vamorolone's efficacy in improving muscle strength with minimal side effects, validated through the pivotal Phase IIb VISION-DMD study. Ultimately, Vamorolone has attained a breakthrough status in DMD treatment. Its endorsement by the FDA underscores Vamorolone as a transformative linchpin, heralding a new era in revolutionizing DMD care.
Sheehan’s syndrome of a 50 years old female with bipolar disorder: a case report
(Medip Academy, 2024-05) Anand, A; Singh, R; Gupta, AK; Kumar, A; Hritika; Kumari, P; Shukla, Shiwani; Kataria, Yuvika
Empty Sella syndrome (ESS) pertains to a phenomenon in which the Turkish sale seems through radiography to be larger and perhaps partially or entirely filled with brain fluids. It can be major illness/ develop as a result of pituitary medical procedures, radiation therapy cerebral infarction/bleeding process. A 50 years old female patient was admitted in emergency medicine ward with chief complaint of pain in abdomen, weakness and vomiting. MRI scan of pituitary cerebrospinal fluid (CSF) signal intensity is seen in Sella with no visible anterior pituitary gland tissue noted-likely suggestive of secondary empty Sella (SES). Long-term steroid use is principal therapy for adrenocorticotropic hormone deficiency (IAD). In this instance, ESS, which can be primary/secondary, also noticed.
Experimental animal models in traumatic brain injury research: a comprehensive review of methods and outlook
(Medip Academy, 2024-06) Saidu, UF; Bulama, I; Onu, A; Abbas, AY; Saidu, Y; Bilbis, LS
Traumatic brain injury (TBI) remains a significant public health concern worldwide, necessitating effective research models to elucidate its pathophysiology and develop therapeutic interventions. Animal models play a crucial role in TBI research, offering valuable insights into injury mechanisms and potential treatments. However, selecting the appropriate model can be challenging due to diverse array of available options and their respective advantages and limitations. In this comprehensive review, we examine four commonly used animal models of TBI: the weight drop, fluid percussion, cortical impact, and blast injury models. Each model is characterized by distinct injury mechanisms, allowing researchers simulate various aspects of TBI pathology. We discuss the unique advantages and disadvantages of each model, providing insights into their applications and considerations for model selection based on research objectives and outcome measures. Furthermore, we highlight emerging directions in TBI modelling, emphasizing the importance of refining and innovating models to replicate the complexity of human TBI. By critically evaluating and understanding the subtlety of different TBI models, researchers can make informed decisions to enhance the translational potential of preclinical TBI research and ultimately improve clinical outcomes for TBI patients.
Assessing the diagnostic impact of P63, PSA and BCL-2 proteins in premalignant and malignant prostate tissues
(Medip Academy, 2024-06) Ogunlayi, AC; Ekundina, VO; Kehinde, AO; Enye, LA; Aremu, AO
Background: Prostate cancer (CaP) is increasingly becoming a major health issue affecting men as cancer-related fatalities are attributable to the condition. Immunohistochemistry (IHC) diagnostic criteria can help in gene-targeted therapy and help reduce its prevalence. This study is to assess the diagnostic impact of prostate-specific antigen (PSA), P63 and BCL-2 antibodies in CaP. Method: A case-controlled retrospective study was carried out on eighty (80) prostrate tissue blocks retrieved from the pathology archive of Ekiti State university teaching hospital Ado Ekiti. IHC analysis of the selected antibodies was carried out and also stained with haematoxylin and eosin (H and E) for second opinion and confirmation. Results: The study showed that all the CaP samples had 100% positivity with varying reactivity to the IHC biomarkers; PSA had 100% positivity and MPR of 94% due to its multiple weaknesses as a biomarker p63 is a basal cells marker. Conclusions: The expressions of these antibodies were observed in the progression of CaP. Although these markers are useful in predicting the progression from benign prostatic hyperplasia (BPH) to CaP, none of them can be utilised in isolation to a conclusion. Hence, they should be used in conjunction with one another to make up for their limitations. The immunohistochemical markers are beneficial in CaP diagnosis.
Nutritional knowledge of in-school adolescents in Sokoto, North-Western Nigeria
(Medip Academy, 2024-05) Mohammad, AU; Jiya, FB
Background: Good nutrition knowledge is a modifiable determinant of dietary behaviours and contributes to strengthen the skills and abilities needed to resist the environmental influences leading to poor dietary habits among adolescents. Objectives were to assess the nutrition knowledge of in-school adolescents in Sokoto, Nigeria and associated factors. Methods: A cross-sectional survey of adolescents selected through multistage random sampling. Data was obtained using pre-tested semi-structured interviewer administered questionnaire. Data was analyzed using IBM® SPSS version 25. Results: A total of 389 subjects were recruited with a mean age of 15.46±1.67 SD and most of them 231 (59.4%) were females. Most 300 (77.1%) of the participants were Hausa, 350 (90%) were Muslims, 278 (71.5%) were from the senior class, and majority 360 (92.5%) resided in urban areas. A large proportion 312 (80.2%) of the participants had good knowledge about classes of food. Only 40 (10.3%) had good knowledge of energy rich food. Two hundred and ninety-eight (76.6%) and 89 (22.9%) had knowledge on high protein diet and good fat diet respectively. Only 107 (27.5%) had good knowledge on minerals and vitamins that are good for bone development. Majority 317 (81.5%) and 341 (87.7%) of the respondents knew eating balanced diet is important and could prevent diseases, respectively. Age category (p=0.007) was the only factor that predicted nutrition knowledge. The main source of nutrition information of the adolescents was teachers 336 (86.4%). Conclusions: Respondents had good knowledge of classes of food. There is however, the need to emphasize on teaching adolescents in the study area about specific nutrient providing meals such as energy rich food, good fat, minerals and vitamins.
Quality of multiple choice question items: item analysis
(Medip Academy, 2024-06) Alemu, AT; Tesfa, H; Mulugeta, A; Fenta, ET; Belay, MA.
Background: There are different types of exam formats for educational assessment. Multiple choice questions (MCQs) are frequently utilized assessment tools in health education. Considering the reliability and validity in developing MCQ items is vital. Educators often face the difficulty of developing credible distractors in MCQ items. Poorly constructed MCQ items make an exam easier or too difficult to be answered correctly by students as intended learning objectives. Checking the quality of MCQ items is overlooked and too little is known about it. Therefore, this study aimed to assess the quality of MCQ items using the item response theory model. Methods: A descriptive cross-sectional study was conducted among MCQ items of public health courses administered to 2nd year nursing students at Injibara university. A total of 50 MCQ items and 200 alternatives were evaluated for statistical item analysis. The quality of MCQ items was assessed by difficulty index (DIF), discrimination index (DI), and distractor efficiency (DE) using students’ exam responses. Microsoft excel sheet and SPSS version 26 were used for data management and analysis. Results: Post-exam item analysis showed that 11 (22%) and 22 (44%) MCQs had too difficult and poor ranges for difficulty and discriminating powers respectively. The overall DE was 71.3%. About forty (20%) distractors were non-functional. Only 8 (16%) MCQs fulfilled the recommended criteria for all-DIF, DI, and DE parameters. Conclusions: The desirable criteria for quality parameters of MCQ items were satisfied only in a few items. The result implies the need for quality improvement. Continuous trainings are required to improve the instructors’ skills to construct quality educational assessment tools.
Atypical electroclinical presentation of Landau Kleffner syndrome: a case report of an 8 year old Nigerian child
(Medip Academy, 2024-04) Nwala, CG; Ejemierele, OM
Epileptic seizures account for common neurologic presentations in paediatric neurology units in developing countries. Atypical presentation of syndromic epilepsy may be missed especially sensory, psychic or autonomic manifestations. An 8 year old male Nigerian child presented with recurrent vomiting and delayed motor milestones, regression of speech (acquired aphasia) with unremarkable birth history or any underlying medical or surgical condition. He had delayed gross motor development and continuous bilateral polyspike waves of slow sleep on EEG. Self-limited autonomic epileptic seizure syndrome which was a strong differential of autonomic seizures in early childhood was not suggestive as his EEG findings failed to demonstrate occipital spike wave pattern nor did photic stimulation evoke any epileptiform waves. Child made significant clinical improvement with anticonvulsants, neuro vitamins, and behavioural therapy, evidenced by regain of non-verbal communication, resolution of autonomic symptoms and temper tantrums. A high index of suspicion should be applied in patients with acquired aphasia with subclinical or recurrent autonomic symptoms.
Genetic diversity and stability analysis based on agro-morphological traits among rice genotypes developed through marker-assisted backcrossing
(Medip Academy, 2024-05) Oginyi, JC; Chukwu, SC; Paul, KU; Mkpuma, KC
Background: The genetic diversity and stability analysis based on agro-morphological traits among rice genotypes developed through SSR marker-assisted backcrossing was evaluated at college of agricultural science (CAS), Ebonyi State niversity, Abakaliki, Nigeria. Methods: In this study, 9 rice accessions sourced from the Iinstitute of tropical agriculture and food security (ITAFoS), universiti Putra, Malaysia and Ebonyi, Nigeria; were evaluated for yield stability performance. The experiments were laid out in randomized complete block design (RCBD) with three replications each for two seasons. Results: Result of the evaluated rice accessions showed highly marked morphological variability based on the mean performance and were grouped into three main clusters. Cluster I had CP, cluster II contained Line4, Line5, Line6, and Line8, and cluster III had Line1, Line7, Line12, and Putra-1. The first, 3 principal components were identified and retained for having the Eigen-value >1. The first PC had an eigenvalue of (6.30) with 52.5% proportion of which plant height accounted most for this variation with (0.359) whereas panicle length contributed the least (-0.13). For stability analysis, CP had highest values for most of the parameters. High heritability value was recorded for all nine traits which range between 71.04% and 95.06%. The highest heritability value (95.06%) was found in Days 50% heading while grain width had the lowest (71.04%). Conclusions: It could be concluded that CP, Putral-1, and line7 were the most stable in terms of yield across the two seasons of this study; hence, recommended for parental materials for hybridization.
Growth and cadmium and nickel uptake of maize (Zea mays L.) in a cadmium and nickel co?contaminated soil and phytoremediation efficiency using ethylenediamine tetraacetic acid
(Medip Academy, 2024-05) Tubotu, FK; Akporhonor, EE; Agbaire, PO
Background: Anthropogenic activities release cadmium (Cd), nickel (Ni), and other heavy metals into soil. Zea mays can clean up contaminated soils, but little is known about how Cd and Ni co-contamination stress affects ethylenediamine tetraacetic acid (EDTA)-based phytoextraction and phytoremediation, hence this study was conducted. Methods: The experiment involved nine treatment levels (0, 5, 10, 15, and 20 mg kg-1 Cd and 0, 15, 30, 45, and 60 mg kg-1 Ni), grouped into three categories: CT as the control group, P as Cd + Ni only, and CAP as Cd + Ni + EDTA (n=3). The treatments used (CH3COO)2Cd•2H2O and NiSO4 as the source of Cd and Ni, respectively, and EDTA was applied at two rates (0 and 0.5 g/kg). After the experimental period, measurements were taken for shoot length, biomass, and metal concentrations in both the roots and shoots using established procedures. Results: The concentrations of metals in plants' roots and shoots increased as the concentrations in soil increased, but shoot length, biomass, bioconcentration factor (BCF), and translocation factor (TF) values decreased with increasing soil metal content. The application of EDTA increased metal uptake but led to greater root and shoot biomass loss. Generally, TF values for Cd and Ni were less than 1 but most of the BCF values were greater than 1. Conclusions: The study found that phytostabilization is the main mechanism for phytoremediation of Cd-Ni-co-contaminated soils with Zea mays, with EDTA addition enhancing metal accumulation and reducing biomass yield.
An analysis of indices and ratios in anthropometric body measurements among team sports athletes
(Medip Academy, 2024-04) Rahman, MH; Sharma, JP
Background: Physical indices and proportions based on anthropometry are crucial for determining the performance of players in team sports. The study aims to analyze the anthropometric status, body mass and shape indices, including waist-to-hip and height ratios, among athletes from different team sports. Methods: Study involved 135 male team-sport athletes specializing in basketball, handball, and volleyball, with 45 players in each sport. Researchers collected anthropometric data, including chronological age (CA), height (Ht), weight (Wt), body mass index (BMI), waist circumferences (WC) and hip circumferences (HC), waist-hip ratio (WHR), waist-height ratio (WHtR), and a body shape index (ABSI). To compare variables across groups, descriptive statistics and one-way ANOVA with LSD post-hoc tests used. Relationships within each group were examined using correlation analysis. Results: The ANOVA findings indicated F-values (2, 132) for CA at 0.57, p=0.57, BMI at 0.59, p=0.56, WC at 2.10, p=0.13, WHR at 1.37, p=0.27, and ABSI at 1.41, p=0.25, respectively, revealing no significant disparities among the groups. Conversely, Ht at 13.36, p=0.00, Wt at 5.74, p=0.00, HC at 6.33, p=0.00, and WHtR at 3.60, p=0.03, respectively, highlighted significant variations between the groups. Furthermore, the correlation of BMI, WC, HC, WHR, WHtR, and ABSI in each group showed a strong positive correlation (p<0.01). Conclusions: Athletes in team sports were found to have similar body mass and shape indices, including ratios for WHR, while the WHtR ratio showed significant variations among the groups. Despite these differences, measures of athletes’ health metrics across these sports remain within safe, normal ranges.
Determinants of small-scale goat production in Mushowani, Zimbabwe
(Medip Academy, 2023-03) Kajevhu, Clapperton; Mabika, Nyasha
Background: Goats are of economic importance to livelihoods of many rural communities in Zimbabwe. Unfortunately, very few farmers are into goat production. Therefore, this study was carried out in order to establish the factors that are affecting goat production in Mushowani, Zimbabwe.Methods: A household survey, using a structured questionnaire was administered in October 2022. The Spearman correlation coefficients were used to test the associations between number of goats against farm size, gender, age, marital status, education, household size, formal training, diseases, income and extension services.Results: Of the 52 respondents surveyed, 59.6% were males and more than half (51.9%) of the farmers attended secondary school, followed by tertiary education (36.6%). Most of the farmers (69.2%) had a herd size of less than 20. The main source of income in the area was the selling of crops. The majority (77%) of the farmers indicated that they planned to increase their goat herd. Goat production in Mushowani is constrained by diseases, feed, water, theft, heat stress, market, transport, veterinary services, insufficient funds, lack of extension services and lack of commercial breeds. Results showed that farm size, age of the farmer, education and extension visits were associated with herd size. Age, education and extension visits were significant at 5%, while farm size was significant at 1%.Conclusions: The results of this study are anticipated to give an insight to the government, policy makers and non-governmental organizations (NGOs) that focus on improving goat production in rural communities.
Prevalence and associated risk factors of neglected tropical diseases in the Amhara region, Ethiopia
(Medip Academy, 2024-03) Tegegne, MW; Damtie, D.
This systematic review analyzed the prevalence of neglected tropical diseases (NTDs) and associated risk factors in the Amhara region. Thirty-one articles from 2012 to 2022 were examined, and data analysis was conducted using STATA version 17. The overall NTD prevalence in Amhara was 29.9% (95% CI: 23.32–36.47). The highest prevalences were observed for soil-transmitted helminths (STHs) at 37.86% (95% CI=27.57–48.15), Schistosoma at 37.77% (95% CI=16.90–58.61), scabies at 24.28% (95% CI=6.42-42.15), and trachoma at 19.55% (95% CI=13.38–25.72). Prevalence varied across zones, ranging from 6.10% (95% CI=4.33–7.87) in Awi to 46.40% (95% CI=42.90–48.80) in Bahir Dar. Factors associated with NTDs included illiteracy and raw vegetable consumption for STHs; male gender, river swimming, and contact with river water for Schistosoma; ocular discharge and fly-eye contact for trachoma; and family size >6, clothes sharing, and sleeping with scabies-infected individuals for scabies. Improved sanitation, health education, and personal hygiene are vital for controlling NTDs in the study region.
The prevalence of premenstrual syndrome symptoms and associated factors among female medical students at Al-Andalus University: a cross-sectional study
(Medip Academy, 2024-04) Salman, SK; Esmandar, DI; Sarem, EK; Attaf, RF
Background: Premenstrual syndrome (PMS) is a menstrual disorder defined as a cluster of various physical, emotional, and behavioural symptoms that negatively affect women’s quality of life. This cross-sectional study aimed to assess the prevalence of common PMS symptoms and determine their association with body mass index (BMI), lifestyle, dietary habits, perceived stress, menstrual flow, family history and family income among medical students at Al-Andalus University in Syria. Methods: A sample of 205 female students were interviewed and filled out a questionnaire. All data were coded and entered into excel (Microsoft 2019). One-way analysis of variance (ANOVA) and Chi-square tests were used to evaluate the association between PMS symptoms and the studied factors. Results: The most frequently reported PMS symptoms were anxiety (80%), bloating (74.6%), and breast tenderness (62.9%). Our study found a significant association between weight gain pre-menstruation and BMI (p=0.02). A significant relationship was found between increased premenstrual consumption of sweets and both breast tenderness and bloating (p=0.01). Daily consumption of coffee was significantly correlated with weight gain and headaches (p<0.001). This study found a significant relationship between smoking cigarettes and abdominal and back pain (p=0.04, p=0.02, respectively). Smoking shisha was significantly associated with fatigue and bloating (p=0.01, p<0.001, respectively). A significant relationship was found between menstrual flow and both abdominal pain and headaches (p=0.01, p=0.02, respectively). Conclusions: A high prevalence of PMS symptoms was reported in Al-Andalus University female medical students. Additionally, this study found multiple significant associations between BMI, dietary habits, lifestyle, menstrual flow and the severity of symptoms.
Predictors of husbands in supporting wives to use obstetrics care services by health professionals, Dire Dawa administration, Ethiopia: a community based cross sectional study
(Medip Academy, 2024-05) Yasin, AM; Tekle, MH; Asegid, DT; Beshir, AB; Amera, TG; Tefera, YM
Background: Husbands’ support in obstetric care services is a process of social and behavioral change that husbands must undergo to prevent obstetric complications. But so far, studies across Ethiopia have been inconsistent and lacking in the study area. Therefore, this study was aimed at assessing husbands’ predictors, which could help in interventions. Methods: A community-based cross-sectional study was conducted in the Dire Dawa administration, Ethiopia, from July 1-30, 2022. Participants were selected using a systematic sampling technique. Data were collected through interviews using a structured questionnaire, entered into EPI data (Version 3.1), and analyzed using SPSS (Version 22). A p=0.05 or less at multivariate with 95% confidence intervals was considered statistically significant. Results: Of a total of 610, 51.8% of husbands support wives in using obstetrics care services. The predictors were urban residence (AOR=2.55, 95% CI: 1.75-3.73), education level of diploma and above (AOR=2.00, 95%CI: 1.10-3.74), perceived importance (AOR=1.98, 95% CI: 1.30-3.00), antenatal care visit accompanying experience (AOR=1.79, 95% CI: 1.04-3.07), and institutional delivery accompanying experience (AOR=6.20, 95% CI: 3.4-1.33). Conclusions: One in two husbands supports wives to use obstetrics care services provided by health professionals. Findings are helpful in advancing knowledge of husbands’ factors and highlight the need for health facilities and stakeholders to strengthen and create continuous community awareness.
Need of rural communities to be engaged and empowered for global health and wellness
(Medip Academy, 2024-04) Chhabra, S.
For health and wellness rural communities do many things with whatever they have, use various modalities of actions for prevention, therapy of disorders, maintenance, promotion of health. Also, for everyday life they do various activities which affect their health. Present article is based on observations, information in context of activities by rural people for their health and wellness. Personal observations, experiences were added to information about actions by rural communities for health and wellness. Rural communities use their own wisdom, do many things with whatever they have for living a healthy life. They use various modalities during pregnancy, birth for mother, new born, persons of all ages. Therapies are used for pregnancy care, birth, post birth, other illnesses, injuries and so on. In modern day practice it has become essential to priorities modes of actions for best therapy, best outcome without harmful effects. In addition to various actions for prevention, therapy, maintenance and promotion of health and wellness, communities do other activities which impact their health. This needs sharing for best of global health. Communities use many modalities for therapy, prevention of disorders, rehabilitation and health promotion. Need is of learning from them, adding science to such modes if needed, robust evaluation of community actions with long term outcomes, cost-effectiveness, in various settings globally. World needs to know and use for healthy life and make communities aware of modern medicine, technology wherever essential for global health.
The role and behaviour of mitochondrial creatine kinase in hepatocellular carcinoma and its potential use as a tumor detecting biomarker for cancer patients
(Medip Academy, 2023-02) Siyahmazgi, Nemati Ali; Mazar, Ghorbani Mina; Vakilinia, Maede; Javid, Hossein
Hepatocellular carcinoma (HCC) is responsible for approximately 75% of all liver cancer cases, which is the seventh most prevalent cancer and the second most common cause of cancer mortality worldwide. The prognosis of HCC depends on its stage and the severity of liver disease at the time of diagnosis, but there are still problems in detecting and treating HCC patients on time and effectively. Being unable to diagnose HCC patients at an early stage and ineffective therapies for HCC patients with advanced stages are associated with the disease's high mortality. Liver transplantation could be a treatment option If patients are diagnosed early, but unfortunately, most patients are diagnosed at an advanced stage where chemotherapy is necessary. Thus, an effective strategy for early detection of HCC is necessary since there was no effective chemotherapy for advanced HCC for a long time, and therapies such as the anti-angiogenesis pathway can only extend the median survival from 7.9 months to 10.7 months which is astep forward but not enough. In this article, we review the role of MtCK in HCC and its potential use as a marker to see if using it can be beneficial to patients.
A meta-analysis evaluating the role of calcium channel alpha-2 delta-1 subunit in carcinogenesis
(Medip Academy, 2024-04) Raybarman, C; Bhattacharjee, S.
There is hardly found any study accumulating all the experiments reported with the expression of alpha-2 delta-1 (?2?-1) in cancer cells. This meta-analysis aimed to advance our knowledge about the role of calcium channel alpha2 delta-1 subunit in carcinogenesis in the present time. PubMed searches for peer-reviewed articles were conducted using the keywords “?2?-1 protein in oncogenesis”, “?2?-1 protein expression in cancer cells”, and “?2?-1 protein as cancer cell marker”. The databases were developed in accordance with PRISMA guidelines. Seventeen studies out of 80 citations met the inclusion criteria pertaining to ?2?-1 expression in different cancer cells. The cancer patterns were hepatocellular carcinoma in 41%, non-small cell lung carcinoma in 12% and laryngeal squamous cell carcinoma in 12%. The remaining studies included small-cell lung cancer (6%), gastric cancer (6%), pancreatic cancer (6%), hypopharyngeal squamous cell carcinoma (6%), breast cancer (6%) and glioblastoma multiforme (6%). ?2?-1+ cells had a higher sphere-forming and tumorigenic efficiency in 76.5% of experiments. 58.8% experiments explored mechanistically in self-renewal efficiency and tumorigenesis of ?2?-1+ cancer cells. The cancer cells expressing ?2?-1 have the potential to serve as cell surface markers for tumour-initiating cells and cancer stem cells. These intriguing findings open up a promising avenue for future research, focusing on the targeting of ?2?-1 as a potential therapeutic strategy for cancer treatment.

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